Serum Glycome Profiling: A Biomarker for Diagnosis
of Ovarian Cancer
Posted on 2016-02-18 - 23:00
During the development of cancer,
changes in cellular glycosylation
are observed, indicating that alterations of the glycome occur in
extracellular fluids as well as in serum and could therefore serve
as tumor biomarkers. In the case of epithelial ovarian cancer (EOC),
common tumor markers such as CA125 are known to have poor specificity;
therefore, better biomarkers are needed. The aim of this work was
to identify new potential glycan biomarkers in EOC-patients. N-Glycans
were cleaved from serum glycoproteins from 63 preoperative primary
EOC-patients along with 33 age-matched healthy women, permethylated,
and analyzed using MALDI-TOF mass spectrometry. A value named GLYCOV
was calculated from the relative areas of the 11 N-glycan biomarkers
revealed by SPSS statistical analyses, namely four high-mannose and
seven complex-type fucosylated N-glycans. GLYCOV diagnosed primary
EOC with a sensitivity of 97% and a specificity of 98.4% whereas CA-125
showed a sensitivity of 97% and a specificity of 88.9%. Our study
is the first one to compare glycan values with the established tumor
marker CA125 and to give better results. Therefore, the N-glycome
could potentially be used as a biomarker.
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Biskup, Karina; Braicu, Elena
I.; Sehouli, Jalid; Fotopoulou, Christina; Tauber, Rudolf; Berger, Markus; et al. (2016). Serum Glycome Profiling: A Biomarker for Diagnosis
of Ovarian Cancer. ACS Publications. Collection. https://doi.org/10.1021/pr400405x
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AUTHORS (7)
KB
Karina Biskup
EB
Elena
I. Braicu
JS
Jalid Sehouli
CF
Christina Fotopoulou
RT
Rudolf Tauber
MB
Markus Berger
VB
Véronique Blanchard