RuPHOX-Ru-Catalyzed Selective Asymmetric Hydrogenation
of Exocyclic α,β-Unsaturated Pentanones
Posted on 2019-08-07 - 17:05
A RuPHOX-Ru catalyzed
selective asymmetric hydrogenation of exocyclic
α,β-unsaturated ketones has been developed, furnishing
the corresponding chiral exocyclic allylic alcohols in high yields
and with up to >99.5% ee. The reaction could be performed on a
gram
scale with a relatively low catalyst loading (up to 10000 S/C) without
any loss in reaction activity and enantioselectivity. The resulting
hydrogenated products could be easily transformed to several biologically
active compounds with high asymmetric performance. The asymmetric
protocol provides an efficient methodology for the synthesis of chiral
exocyclic allylic alcohols.
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Li, Jing; Zhu, Yue; Lu, Yufei; Wang, Yanzhao; Liu, Yangang; Liu, Delong; et al. (2019). RuPHOX-Ru-Catalyzed Selective Asymmetric Hydrogenation
of Exocyclic α,β-Unsaturated Pentanones. ACS Publications. Collection. https://doi.org/10.1021/acs.organomet.9b00366
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AUTHORS (7)
JL
Jing Li
YZ
Yue Zhu
YL
Yufei Lu
YW
Yanzhao Wang
YL
Yangang Liu
DL
Delong Liu
WZ
Wanbin Zhang