Rh(I)-Catalyzed Alkylation of <i>ortho</i>-C–H Bonds in Aromatic Amides with Maleimides

Published on 2017-08-11T20:29:42Z (GMT) by
An alkylation of C–H bonds with maleimides by a rhodium-catalyzed reaction of aromatic amides containing an 8-aminoquinoline moiety as the directing group is reported. Various <i>N</i>-substituents in the maleimide, including methyl, ethyl, cyclohexyl, benzyl, and phenyl groups and even H, are applicable to the reaction. The reaction is highly regioselective at the less hindered <i>ortho</i>-C–H bond when <i>meta</i>-substituted aromatic amides are used as substrates.

Cite this collection

He, Qiyuan; Yamaguchi, Takuma; Chatani, Naoto (2017): Rh(I)-Catalyzed Alkylation of ortho-C–H Bonds in Aromatic Amides with Maleimides. ACS Publications.

https://doi.org/10.1021/acs.orglett.7b02135

Retrieved: 16:51, Aug 22, 2017 (GMT)