Rh(I)-Catalyzed Alkylation of ortho-C–H Bonds in Aromatic Amides with Maleimides
Posted on 2017-08-11 - 20:29
An
alkylation of C–H bonds with maleimides by a rhodium-catalyzed
reaction of aromatic amides containing an 8-aminoquinoline moiety
as the directing group is reported. Various N-substituents
in the maleimide, including methyl, ethyl, cyclohexyl, benzyl, and
phenyl groups and even H, are applicable to the reaction. The reaction
is highly regioselective at the less hindered ortho-C–H bond when meta-substituted aromatic
amides are used as substrates.
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He, Qiyuan; Yamaguchi, Takuma; Chatani, Naoto (2017). Rh(I)-Catalyzed Alkylation of ortho-C–H Bonds in Aromatic Amides with Maleimides. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b02135
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AUTHORS (3)
QH
Qiyuan He
TY
Takuma Yamaguchi
NC
Naoto Chatani