Regulating DNA-Hybridization
Using a Chemically Fueled
Reaction Cycle
Posted on 2022-11-29 - 01:06
Molecular machines, such as ATPases or motor proteins,
couple the
catalysis of a chemical reaction, most commonly hydrolysis of nucleotide
triphosphates, to their conformational change. In essence, they continuously
convert a chemical fuel to drive their motion. An outstanding goal
of nanotechnology remains to synthesize a nanomachine with similar
functions, precision, and speed. The field of DNA nanotechnology has
given rise to the engineering precision required for such a device.
Simultaneously, the field of systems chemistry developed fast chemical
reaction cycles that convert fuel to change the function of molecules.
In this work, we thus combined a chemical reaction cycle with the
precision of DNA nanotechnology to yield kinetic control over the
conformational state of a DNA hairpin. Future work on such systems
will result in out-of-equilibrium DNA nanodevices with precise functions.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Stasi, Michele; Monferrer, Alba; Babl, Leon; Wunnava, Sreekar; Dirscherl, Christina Felicitas; Braun, Dieter; et al. (2022). Regulating DNA-Hybridization
Using a Chemically Fueled
Reaction Cycle. ACS Publications. Collection. https://doi.org/10.1021/jacs.2c08463
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (9)
MS
Michele Stasi
AM
Alba Monferrer
LB
Leon Babl
SW
Sreekar Wunnava
CD
Christina Felicitas Dirscherl
DB
Dieter Braun
PS
Petra Schwille
HD
Hendrik Dietz
JB
Job Boekhoven
KEYWORDS
yield kinetic controlequilibrium dna nanodevicesengineering precision requiredchemical reaction cyclechemical reactionchemical fuelregulating dnadna nanotechnologydna hairpinthus combinedsimilar functionsprecise functionsoutstanding goalnucleotide triphosphatesnanotechnology remainsmotor proteinshybridization usinggiven riseconvert fuelcontinuously convertconformational statecommonly hydrolysis