Regiodivergent Ring-Opening Cross-Coupling of Vinyl
Aziridines with Phosphorus Nucleophiles: Access to Phosphorus-Containing
Amino Acid Derivatives
Version 2 2018-11-08, 21:44
Version 1 2018-11-02, 14:50
Posted on 2018-11-08 - 21:44
Catalytic
ring-opening phosphonation and phosphatation of vinyl
aziridines have been developed in a regiodivergent fashion, giving
linear and branched products. Generation of P-centered radicals enables
SN2′-type ring-opening reactions of vinyl aziridines
to afford δ-amino alkylphosphorus products at room temperature.
On the other hand, in situ generated phosphate anions via the Ag-catalyzed
aerobic oxidation of phosphonyl reactants underwent SN2
reaction to provide branched phosphorus-containing amine products.
Furthermore, this divergent methodology serves as a powerful tool
for the stereospecific synthesis of phosphorus-containing amino acid
derivatives.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Kang, Dahye; Kim, Taehwan; Lee, Hyunpyo; Hong, Sungwoo (2018). Regiodivergent Ring-Opening Cross-Coupling of Vinyl
Aziridines with Phosphorus Nucleophiles: Access to Phosphorus-Containing
Amino Acid Derivatives. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b03309
or
Select your citation style and then place your mouse over the citation text to select it.