Quartz Crystal Microbalance Model for Quantitatively
Probing the Deformation of Adsorbed Particles at Low Surface Coverage
Version 4 2018-09-21, 08:15
Version 3 2017-12-01, 07:29
Version 2 2017-10-11, 18:57
Version 1 2017-10-11, 18:55
Posted on 2018-09-21 - 08:15
Characterizing
the deformation of nanoscale, soft-matter particulates
at solid–liquid interfaces is a demanding task, and there are
limited experimental options to perform quantitative measurements
in a nonperturbative manner. Previous attempts, based on the quartz
crystal microbalance (QCM) technique, focused on the high surface
coverage regime and modeled the adsorbed particles as a homogeneous
film, while not considering the coupling between particles and surrounding
fluid and hence resulting in an underestimation of the known particle
height. In this work, we develop a model for the hydrodynamic coupling
between adsorbed particles and surrounding fluid in the limit of a
low surface coverage, which can be used to extract shape information
from QCM measurement data. We tackle this problem by using hydrodynamic
simulations of an ellipsoidal particle on an oscillating surface.
From the simulation results, we derived a phenomenological relation
between the aspect ratio r of the absorbed particles
and the slope and intercept of the line that fits instantaneous, overtone-dependent
QCM data on (δ/a, −Δf/n) coordinates where δ is the viscous penetration
depth, a is the particle radius, Δf is the QCM frequency shift, and n is the overtone
number. The model was applied to QCM measurement data pertaining to
the adsorption of 34 nm radius, fluid-phase and gel-phase liposomes
onto a titanium oxide-coated surface. The osmotic pressure across
the liposomal bilayer was varied to induce shape deformation. By combining
these results with a membrane bending model, we determined the membrane
bending energy for the gel-phase liposomes, and the results are consistent
with literature values. In summary, a phenomenological model is presented
and validated in order to show for the first time that QCM experiments
can quantitatively measure the deformation of adsorbed particles at
low surface coverage.
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Gillissen, Jurriaan
J. J.; Jackman, Joshua A.; Tabaei, Seyed R.; Yoon, Bo Kyeong; Cho, Nam-Joon (2017). Quartz Crystal Microbalance Model for Quantitatively
Probing the Deformation of Adsorbed Particles at Low Surface Coverage. ACS Publications. Collection. https://doi.org/10.1021/acs.analchem.7b03179
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AUTHORS (5)
JG
Jurriaan
J. J. Gillissen
JJ
Joshua A. Jackman
ST
Seyed R. Tabaei
BY
Bo Kyeong Yoon
NC
Nam-Joon Cho