Polymorphism of R‑Encenicline Hydrochloride:
Access to the Highest Number of Structurally Characterized Polymorphs
Using Desolvation of Various Solvates
Version 2 2019-07-18, 19:15
Version 1 2019-07-18, 18:45
Posted on 2019-07-18 - 19:15
In
a study of the solid form landscape of R-encenicline hydrochloride
(Enc-HCl), it was found that this compound is dodecamorphic and presents
the first published example of polymorphism with a record-breaking
10 solved crystal structures. In addition to the four known polymorphs,
eighth new polymorphs and their precursor solvates as well as several
new hydrates have been characterized. The polymorph formation behavior
is investigated by analyzing crystal structures of polymorphs and
solvates used in their preparation. Molecular packing in crystal structures
of the polymorphs is highly similar to that in the precursor solvates,
whereas conformations in all structures are nearly identical and correspond
to the same energy minimum.
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Kons, Artis; Be̅rziņš, Agris; Actiņš, Andris; Rekis, Toms; Smaalen, Sander van; Mishnev, Anatoly (2019). Polymorphism of R‑Encenicline Hydrochloride:
Access to the Highest Number of Structurally Characterized Polymorphs
Using Desolvation of Various Solvates. ACS Publications. Collection. https://doi.org/10.1021/acs.cgd.9b00648
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AUTHORS (6)
AK
Artis Kons
AB
Agris Be̅rziņš
AA
Andris Actiņš
TR
Toms Rekis
SS
Sander van Smaalen
AM
Anatoly Mishnev