Alpha-Particle Emitting 213Bi-Anti-EGFR Immunoconjugates Eradicate Tumor Cells Independent of Oxygenation
Posted on 2013-05-28 - 02:04
Culture flasks were arranged in three levels, separated by lead plates (thickness 1.31 cm; distance 6.5 cm). Thus, irradiation doses were reduced by half (D1, D1/2, D1/4), respectively, as confirmed by dosimetric measurements. Cells were irradiated with three different doses in one irradiation experiment. Hypoxia was established by repeated aspiration of air and influx of 95% N2, 5% CO2.
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Wulbrand, Christian; Seidl, Christof; C. Gaertner, Florian; Bruchertseifer, Frank; Morgenstern, Alfred; Essler, Markus; et al. (2015). Alpha-Particle Emitting 213Bi-Anti-EGFR Immunoconjugates Eradicate Tumor Cells Independent of Oxygenation. PLOS ONE. Collection. https://doi.org/10.1371/journal.pone.0064730
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AUTHORS (7)
CW
Christian Wulbrand
CS
Christof Seidl
FC
Florian C. Gaertner
FB
Frank Bruchertseifer
AM
Alfred Morgenstern
ME
Markus Essler
RS
Reingard Senekowitsch-Schmidtke