Phloroglucinols from the Roots of Garcinia
dauphinensis and Their Antiproliferative and Antiplasmodial
Activities
Posted on 2018-10-24 - 19:16
Garcinia dauphinensis is a previously uninvestigated
endemic plant species of Madagascar. The new phloroglucinols dauphinols
A–F and 3′-methylhyperjovoinol B (1–7) and six known phloroglucinols (8–13) together with tocotrienol 14 and the three
triterpenoids 15–17 were isolated
from an ethanolic extract of G. dauphinensis roots
using various chromatographic techniques. The structures of the isolated
compounds were elucidated by NMR, MS, optical rotation, and ECD data.
Theoretical ECD spectra and specific rotations for 2 were
calculated and compared to experimental data in order to assign its
absolute configuration. Among the compounds tested, 1 showed the most promising growth inhibitory activity against A2870
ovarian cancer cells, with IC50 = 4.5 ± 0.9 μM,
while 2 had good antiplasmodial activity against the
Dd2 drug-resistant strain of Plasmodium falciparum, with IC50 = 0.8 ± 0.1 μM.
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Fuentes, Rolly
G.; Pearce, Kirk C.; Du, Yongle; Rakotondrafara, Andriamalala; Valenciano, Ana L.; Cassera, Maria B.; et al. (2018). Phloroglucinols from the Roots of Garcinia
dauphinensis and Their Antiproliferative and Antiplasmodial
Activities. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.8b00379
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AUTHORS (9)
RF
Rolly
G. Fuentes
KP
Kirk C. Pearce
YD
Yongle Du
AR
Andriamalala Rakotondrafara
AV
Ana L. Valenciano
MC
Maria B. Cassera
VR
Vincent E. Rasamison
TC
T. Daniel Crawford
DG
David G. I. Kingston