Phenylpropane as an Alternative Dearomatizing Unit
of Indoles: Discovery of Inaequalisines A and B Using Substructure-Informed
Molecular Networking

Beniddir, Mehdi A.

Phenylpropane as an Alternative Dearomatizing Unit of Indoles: Discovery of Inaequalisines A and B Using Substructure-Informed Molecular Networking

Posted on 2020-07-20 - 15:11

Inaequalisines A and B (1 and 2), the first examples of hybrid alkylated phenylpropane monoterpene indole alkaloids, were isolated from the roots of Callichilia inaequalis, guided by the combined use of molecular networking and substructure annotation. Their structures, including absolute configuration, were elucidated by spectroscopic methods and ECD calculations. A possible biosynthetic pathway for 1 and 2 was postulated.

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Cauchie, Gaëla; N’Nang, Elvis Otogo; van der Hooft, Justin J. J.; Le Pogam, Pierre; Bernadat, Guillaume; Gallard, Jean-François; et al. (2020). Phenylpropane as an Alternative Dearomatizing Unit of Indoles: Discovery of Inaequalisines A and B Using Substructure-Informed Molecular Networking. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c02153

https://doi.org/10.1021/acs.orglett.0c02153

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