Phenanthroline‑tBuOK Promoted
Intramolecular C–H Arylation of Indoles with ArI under Transition-Metal-Free
Conditions
Posted on 2018-12-06 - 13:19
The
first example of phenanthroline-tBuOK
promoted intramolecular radical C–H arylation of N-(2-iodobenzyl)indoles without involvement of transition
metals has been developed. A variety of substituted 6H-isoindolo [2, 1-a] indoles were prepared by a simple and efficient
intramolecular cyclization using 1,10-phenanthroline in the presence
of potassium tert-butoxide and chlorobenzene. This
strategy provides a fast and versatile access to isoindolo[2,1-a]indole derivatives for the synthesis of pharmaceuticals
and organic electroluminescent (EL) materials.
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Shan, Xiang-Huan; Yang, Bo; Zheng, Hong-Xing; Qu, Jian-Ping; Kang, Yan-Biao (2018). Phenanthroline‑tBuOK Promoted
Intramolecular C–H Arylation of Indoles with ArI under Transition-Metal-Free
Conditions. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b03449
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AUTHORS (5)
XS
Xiang-Huan Shan
BY
Bo Yang
HZ
Hong-Xing Zheng
JQ
Jian-Ping Qu
YK
Yan-Biao Kang
KEYWORDS
Indolepotassium tertphenanthrolinechlorobenzenetransition metalsindoleArylationvarietyisoindoloaccessstrategyelectroluminescentderivativesynthesisELarylationpharmaceuticalTransition-Metal-Free Conditionspresencematerial6 Ht BuOKPromotedArIintramolecular cyclizationPhenanthrolinebutoxideiodobenzylIntramolecularinvolvement1-