Phase-Constrained Spectrum Deconvolution for Fourier
Transform Mass Spectrometry
Version 3 2017-12-16, 19:14
Version 2 2017-10-27, 17:18
Version 1 2016-12-23, 19:59
Posted on 2017-12-16 - 19:14
This
Article introduces a new computationally efficient noise-tolerant
signal processing method, referred to as phased spectrum deconvolution
method (ΦSDM), designed for Fourier transform mass spectrometry
(FT MS). ΦSDM produces interference-free mass spectra with resolution
beyond the Fourier transform
(FT) uncertainty limit. With a presumption that the oscillation phases
are preserved, the method deconvolves an observed FT spectrum into
a distribution of harmonic components bound to a fixed frequency grid,
which is several times finer than that of FT. The approach shows stability
under noisy conditions, and the noise levels in the resulting spectra
are lower than those of the original FT spectra. Although requiring
more computational power than standard FT algorithms, ΦSDM runs
in a quasilinear time. The method was tested on both synthetic and
experimental data, and consistently demonstrated performance superior
to the FT-based methodologies, be it across the entire mass range
or on a selected mass window of interest. ΦSDM promises substantial
improvements in the spectral quality and the speed of FT MS instruments.
It might also be beneficial for other spectroscopy approaches which
require harmonic analysis for data processing.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Grinfeld, Dmitry; Aizikov, Konstantin; Kreutzmann, Arne; Damoc, Eugen; Makarov, Alexander (2016). Phase-Constrained Spectrum Deconvolution for Fourier
Transform Mass Spectrometry. ACS Publications. Collection. https://doi.org/10.1021/acs.analchem.6b03636
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (5)
DG
Dmitry Grinfeld
KA
Konstantin Aizikov
AK
Arne Kreutzmann
ED
Eugen Damoc
AM
Alexander Makarov