Nuclear Overhauser Enhancement Mediated Chemical Exchange Saturation Transfer Imaging at 7 Tesla in Glioblastoma Patients

Left frontal glioblastoma in a 59 year old man at 3 Tesla, CE-T1 (A) and T2-weighted images (B). On the selected slice the CEST contrast at 7 Tesla, based on MTR_asym (C), displays peritumoral hyperintensities at equal extent compared to the edema on T2-weighted images. In contrast to T2-weighted images, the CEST peritumoral hyperintensity displays an irregular border and subareas of different signal intensity.