Performance of an electronic health record-based phenotype algorithm to identify community associated methicillin-resistant Staphylococcus aureus cases and controls for genetic association studies
Posted on 2016-11-17 - 05:00
Abstract Background Community associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is one of the most common causes of skin and soft tissue infections in the United States, and a variety of genetic host factors are suspected to be risk factors for recurrent infection. Based on the CDC definition, we have developed and validated an electronic health record (EHR) based CA-MRSA phenotype algorithm utilizing both structured and unstructured data. Methods The algorithm was validated at three eMERGE consortium sites, and positive predictive value, negative predictive value and sensitivity, were calculated. The algorithm was then run and data collected across seven total sites. The resulting data was used in GWAS analysis. Results Across seven sites, the CA-MRSA phenotype algorithm identified a total of 349 cases and 7761 controls among the genotyped European and African American biobank populations. PPV ranged from 68 to 100% for cases and 96 to 100% for controls; sensitivity ranged from 94 to 100% for cases and 75 to 100% for controls. Frequency of cases in the populations varied widely by site. There were no plausible GWAS-significant (pâ<â5 E â8) findings. Conclusions Differences in EHR data representation and screening patterns across sites may have affected identification of cases and controls and accounted for varying frequencies across sites. Future work identifying these patterns is necessary.
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Jackson, Kathryn; Mbagwu, Michael; Pacheco, Jennifer; Baldridge, Abigail; Viox, Daniel; Linneman, James; et al. (2016). Performance of an electronic health record-based phenotype algorithm to identify community associated methicillin-resistant Staphylococcus aureus cases and controls for genetic association studies. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3614693.v1
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AUTHORS (17)
KJ
Kathryn Jackson
MM
Michael Mbagwu
JP
Jennifer Pacheco
AB
Abigail Baldridge
DV
Daniel Viox
JL
James Linneman
SS
Sanjay Shukla
PP
Peggy Peissig
KB
Kenneth Borthwick
DC
David Carrell
SB
Suzette Bielinski
JK
Jacqueline Kirby
JD
Joshua Denny
FM
Frank Mentch
LV
Lyam Vazquez
LR
Laura Rasmussen-Torvik
AK
Abel Kho