Pd-Catalyzed, <i>ortho</i> C–H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups
Published on 2018-02-13T11:13:47Z (GMT) by
The direct, Pd-catalyzed <i>ortho</i> C–H methylation and fluorination of benzaldehydes have been accomplished using commercially available orthanilic acids as transient directing groups. In these reactions, the 1-fluoro-2,4,6-trimethylpyridinium salts can be either a bystanding F<sup>+</sup> oxidant or an electrophilic fluorinating reagent. An X-ray crystal structure of a benzaldehyde <i>ortho</i> C–H palladation intermediate was obtained using triphenylphosphine as the stabilizing ligand.
Cite this collection
Chen, Xiao-Yang; Sorensen, Erik J. (2018): Pd-Catalyzed, ortho C–H Methylation
and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient
Directing Groups. ACS Publications.