Parallel Kinetic Resolution of Racemic
Aldehydes by Use of Asymmetric
Horner−Wadsworth−Emmons Reactions

Reiser, Oliver

Parallel Kinetic Resolution of Racemic Aldehydes by Use of Asymmetric Horner−Wadsworth−Emmons Reactions

Posted on 2000-01-29 - 00:00

A racemic aldehyde can undergo parallel kinetic resolution (PKR) by simultaneous reaction with two different chiral phosphonates, differing either in the structure of the chiral auxiliary or in the structure of the phosphoryl group (i.e., one (E)- and one (Z)-selective reagent). This strategy allows conversion of a racemic aldehyde to two different, synthetically useful chiral products with essentially doubled material throughput and similar or improved selectivities as compared to conventional kinetic resolution.

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Pedersen, Torben M.; Jensen, Jakob F.; Humble, Rikke E.; Rein, Tobias; Tanner, David; Bodmann, Kerstin; et al. (2016). Parallel Kinetic Resolution of Racemic Aldehydes by Use of Asymmetric Horner−Wadsworth−Emmons Reactions. ACS Publications. Collection. https://doi.org/10.1021/ol991387h

https://doi.org/10.1021/ol991387h

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