Palladium-Catalyzed Four-Component Cascade Reaction
for the Synthesis of Highly Functionalized Acyclic O,O‑Acetals

Jiang, Huanfeng

Palladium-Catalyzed Four-Component Cascade Reaction for the Synthesis of Highly Functionalized Acyclic O,O‑Acetals

Posted on 2018-01-16 - 22:44

A palladium-catalyzed four-component cascade reaction of carbon dioxide, amines, allenyl ethers, and aryl iodides has been developed for the first time. The novel reaction allows simultaneous construction of three different new bonds (C–N, C–O, and C–C) in a single step, affording an efficient method for the synthesis of a variety of highly functionalized acyclic O,O-acetals. Excellent chemo- and regioselectivity, wide substrate scope, and good functional group tolerance are features of the method.

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Xiong, Wenfang; Yan, Donghao; Qi, Chaorong; Jiang, Huanfeng (2018). Palladium-Catalyzed Four-Component Cascade Reaction for the Synthesis of Highly Functionalized Acyclic O,O‑Acetals. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b03808

https://doi.org/10.1021/acs.orglett.7b03808

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