Organocatalytic Ring-Opening Polymerization Toward
Poly(γ-amide-ε-caprolactone)s with Tunable Lower Critical
Solution Temperatures
Posted on 2020-07-01 - 15:33
γ-Amide-ε-caprolactones
including 7-oxo-N-propyloxepane-4-carboxamide (NNCL), N-isopropyl-7-oxooxepane-4-carboxamide (NICL), N,N-diethyl-7-oxooxepane-4-carboxamide (DECL), and
5-(pyrrolidine-1-carbonyl)oxepan-2-one (VPyCL) were initially designed
and synthesized to achieve biodegradable and thermosensitive materials.
Ring-opening polymerization (ROP) of these newly developed caprolactones
was thoroughly investigated by both theoretical calculation and experimental
verification. Density functional theory revealed that the ring-opening
enthalpy of γ-amide-ε-caprolactones was more negative
than that of γ-ester-ε-caprolactone (EMCL). Experimental results showed that ROP of NICL,
DECL, and VPyCL catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene with
benzyl alcohol (BnOH) as an initiator underwent in a living and controlled
manner, while that of NNCL and EMCL did not. Computational calculation
consistently proved that a variety of substitutions greatly affected
the ROP process. PNICL, PDECL, and PVPyCL exhibited reversible lower
critical solution temperature-type phase transitions tuned by manipulating
the feed ratio and hydrophilicity of comonomers. Furthermore, poly(γ-amide-ε-caprolactone)s with
excellent biodegradability and biocompatibility were demonstrated
as an enzyme activity regulator, holding great promise for smart biomaterial
application.
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Wen, Lianlei; Zhang, Shaoze; Xiao, Yan; He, Jin; Zhu, Shuang; Zhang, Jun; et al. (2020). Organocatalytic Ring-Opening Polymerization Toward
Poly(γ-amide-ε-caprolactone)s with Tunable Lower Critical
Solution Temperatures. ACS Publications. Collection. https://doi.org/10.1021/acs.macromol.0c00253
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AUTHORS (8)
LW
Lianlei Wen
SZ
Shaoze Zhang
YX
Yan Xiao
JH
Jin He
SZ
Shuang Zhu
JZ
Jun Zhang
ZW
Zihan Wu
ML
Meidong Lang
KEYWORDS
NNCL7- oxopropyloxepane -4-carboxamideVPyCLCritical Solution Temperatures γPDECLExperimental resultsring-opening enthalpyEMCLbiomaterial applicationisopropyl -7-oxooxepanesolution temperature-type phase tra...ROP processthermosensitive materialsγ- amide -ε-caprolactonesPNICLbenzyl alcoholenzyme activity regulatorRing-opening polymerizationDECLOrganocatalytic Ring-Opening Polyme...diethyl -7-oxooxepaneComputational calculationfeed ratioNICL