Organelle-Partitioned Sugar–Rhodamine Diad
for In Vivo Tumor Imaging
Posted on 2020-07-23 - 12:07
Current tumor imaging
agents are often limited by their liability
to dissipate from tumor tissues. As cell sugar sorting enables exogenous
sugars to be delivered into predetermined subcellular locations, we
synthesized sialic acid (Sia) derivatives with rhodamine-X conjugated
at C-9 (ROXSia), which hitchhikes cell sialic acid sorting
to target tumor cell lysosomes, exhibiting pH-independent long-term
probe retention in lysosomes. ROXSia gives selective, bright,
and endured fluorescence signals in subcutaneous tumors and orthotopic
tumors in mice models. These results indicate the potential of ROXSia as a lysosome-targeted optical agent for fluorescence-guided
tumor resection.
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Zhang, Enkang; Yu, Chaozhang; Tang, Hui; Li, Yuntong; Zuo, Dongliang; Yang, Rongshui; et al. (2020). Organelle-Partitioned Sugar–Rhodamine Diad
for In Vivo Tumor Imaging. ACS Publications. Collection. https://doi.org/10.1021/acsomega.0c02323
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AUTHORS (10)
EZ
Enkang Zhang
CY
Chaozhang Yu
HT
Hui Tang
YL
Yuntong Li
DZ
Dongliang Zuo
RY
Rongshui Yang
CM
Chao Ma
JM
Jiayin Miao
PL
Pingguo Liu
XS
Xinhui Su