Nucleoside-Lipid-Based Nanocarriers for Sorafenib Delivery
Posted on 2018-01-11 - 05:00
Abstract Although the application of sorafenib, a small inhibitor of tyrosine protein kinases, to cancer treatments remains a worldwide option in chemotherapy, novel strategies are needed to address the low water solubility (< 5 μM), toxicity, and side effects issues of this drug. In this context, the use of nanocarriers is currently investigated in order to overcome these drawbacks. In this contribution, we report a new type of sorafenib-based nanoparticles stabilized by hybrid nucleoside-lipids. The solid lipid nanoparticles (SLNs) showed negative or positive zeta potential values depending on the nucleoside-lipid charge. Transmission electron microscopy of sorafenib-loaded SLNs revealed parallelepiped nanoparticles of about 200 nm. Biological studies achieved on four different cell lines, including liver and breast cancers, revealed enhanced anticancer activities of Sorafenib-based SLNs compared to the free drug. Importantly, contrast phase microscopy images recorded after incubation of cancer cells in the presence of SLNs at high concentration in sorafenib (> 80 μM) revealed a total cancer cell death in all cases. These results highlight the potential of nucleoside-lipid-based SLNs as drug delivery systems.
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Benizri, Sebastien; Ferey, Ludivine; Alies, Bruno; Mebarek, Naila; Vacher, Gaelle; Appavoo, Ananda; et al. (2018). Nucleoside-Lipid-Based Nanocarriers for Sorafenib Delivery. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3975189.v1
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AUTHORS (9)
SB
Sebastien Benizri
LF
Ludivine Ferey
BA
Bruno Alies
NM
Naila Mebarek
GV
Gaelle Vacher
AA
Ananda Appavoo
CS
Cathy Staedel
KG
Karen Gaudin
PB
Philippe Barthélémy