Novel Biomedical Functions of Surfactin A from Bacillus
subtilis in Wound Healing Promotion and
Scar Inhibition
Posted on 2020-06-17 - 14:03
Surfactin
produced by Bacillus subtilis is a
powerful biosurfactant in food, cosmetics, and pesticide industries.
However, its suitability in wound healing applications is uncertain.
In this article, we determined the effects of surfactin A from B. subtilis on wound healing, angiogenesis, cell
migration, inflammatory response, and scar formation. The results
indicated that 80.65 ± 2.03% of surfactin A-treated wounds were
closed, whereas 44.30 ± 4.26% of the vehicle-treated wound areas
remained open on day 7 (P < 0.05). In mechanisms,
it upregulated the expression of hypoxia-inducible factor-1α
(HIF-1α) and vascular endothelial growth factor (VEGF), accelerated
keratinocyte migration through mitogen-activated protein kinase (MAPK)
and nuclear factor-κB (NF-κB) signaling pathways, and
regulated the secretion of proinflammatory cytokines and macrophage
phenotypic switch. More attractive, surfactin A showed a seductive
capability to inhibit scar tissue formation by affecting the expression
of α-smooth muscle actin (α-SMA) and transforming growth
factor (TGF-β). Overall, the study revealed a new function and
potential of surfactin A as an affordable and efficient wound healing
drug.
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Yan, Lu; Liu, Guanwen; Zhao, Bin; Pang, Bing; Wu, Wanqin; Ai, Chongyang; et al. (2020). Novel Biomedical Functions of Surfactin A from Bacillus
subtilis in Wound Healing Promotion and
Scar Inhibition. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.0c01658
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AUTHORS (14)
LY
Lu Yan
GL
Guanwen Liu
BZ
Bin Zhao
BP
Bing Pang
WW
Wanqin Wu
CA
Chongyang Ai
XZ
Xixi Zhao
XW
Xinglong Wang
CJ
Chunmei Jiang
DS
Dongyan Shao
QL
Qianlong Liu
ML
Meixuan Li
LW
Lei Wang
JS
Junling Shi
KEYWORDS
migrationmacrophage phenotypic switchVEGFmitogen-activated protein kinaseBacillus subtilisWound Healing Promotionscar tissue formationgrowth factorexpressionScar Inhibition Surfactinsurfactin A-treated woundsSMAvehicle-treated wound areasNFwound healing drugwound healing applicationsNovel Biomedical Functions-κBhypoxia-inducible factor -1αTGFHIFMAPK