Nototronesides A–C, Three Triterpene Saponins
with a 6/6/9 Fused Tricyclic Tetranordammarane Carbon Skeleton from
the Leaves of Panax notoginseng
Posted on 2018-07-18 - 17:54
Three triterpene
saponins, nototronesides A–C (1–3), possessing an unprecedented 6/6/9 fused
tricyclic tetranordammarane core, were isolated from the leaves of Panax notoginseng. Their structures were elucidated on the
basis of spectroscopic data, and the structure of sapogenin (1a) was further confirmed by X-ray crystallography. The existence
of 1–3 adds a new dimension to the
diversity of the triterpene family. Moreover, compound 2 showed a moderate neuroprotective effect on serum deficiency-induced
cellular damage in PC12 cells.
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Liu, Xin-Yi; Li, Chuang-Jun; Chen, Fang-You; Ma, Jie; Wang, Shuo; Yuan, Yu-He; et al. (2018). Nototronesides A–C, Three Triterpene Saponins
with a 6/6/9 Fused Tricyclic Tetranordammarane Carbon Skeleton from
the Leaves of Panax notoginseng. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b01848
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AUTHORS (8)
XL
Xin-Yi Liu
CL
Chuang-Jun Li
FC
Fang-You Chen
JM
Jie Ma
SW
Shuo Wang
YY
Yu-He Yuan
LL
Li Li
DZ
Dong-Ming Zhang