Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow
Published on 2018-02-12T20:20:25Z (GMT) by
An electrochemically driven, nickel-catalyzed reductive coupling of <i>N</i>-hydroxyphthalimide esters with aryl halides is reported. The reaction proceeds under mild conditions in a divided electrochemical cell and employs a tertiary amine as the reductant. This decarboxylative C(sp<sup>3</sup>)–C(sp<sup>2</sup>) bond-forming transformation exhibits excellent substrate generality and functional group compatibility. An operationally simple continuous-flow version of this transformation using a commercial electrochemical flow reactor represents a robust and scalable synthesis of value added coupling process.
Cite this collection
Li, Hui; Breen, Christopher P.; Seo, Hyowon; Jamison, Timothy F.; Fang, Yuan-Qing; Bio, Matthew M. (2018): Ni-Catalyzed Electrochemical Decarboxylative C–C
Couplings in Batch and Continuous Flow. ACS Publications. Collection.