NANPDB: A Resource for Natural Products from Northern
African Sources
Version 2 2020-09-10, 18:36
Version 1 2017-06-22, 17:34
Posted on 2020-09-10 - 18:36
Natural products (NPs) are often regarded as sources of drugs or
drug leads or simply as a “source of inspiration” for
the discovery of novel drugs. We have built the Northern African Natural
Products Database (NANPDB) by collecting information on ∼4500
NPs, covering literature data for the period from 1962 to 2016. The
data cover compounds isolated mainly from plants, with contributions
from some endophyte, animal (e.g., coral), fungal, and bacterial sources.
The compounds were identified from 617 source species, belonging to
146 families. Computed physicochemical properties, often used to predict
drug metabolism and pharmacokinetics, as well as predicted toxicity
information, have been included for each compound in the data set.
This is the largest collection of annotated natural compounds produced
by native organisms from Northern Africa. While the database includes
well-known drugs and drug leads, the medical potential of a majority
of the molecules is yet to be investigated. The database could be
useful for drug discovery efforts, analysis of the bioactivity of
selected compounds, or the discovery of synthesis routes toward secondary
metabolites. The current version of NANPDB is available at http://african-compounds.org/nanpdb/.
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Ntie-Kang, Fidele; Telukunta, Kiran K.; Döring, Kersten; Simoben, Conrad V.; Moumbock, Aurélien
F. A.; Malange, Yvette I.; et al. (2017). NANPDB: A Resource for Natural Products from Northern
African Sources. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.7b00283
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AUTHORS (10)
FN
Fidele Ntie-Kang
KT
Kiran K. Telukunta
KD
Kersten Döring
CS
Conrad V. Simoben
AM
Aurélien
F. A. Moumbock
YM
Yvette I. Malange
LN
Leonel E. Njume
JY
Joseph N. Yong
WS
Wolfgang Sippl
SG
Stefan Günther