Multifunctional
Double-Bundle DNA Tetrahedron for
Efficient Regulation of Gene Expression
Posted on 2020-07-14 - 06:29
DNA
nanostructures have garnered considerable interest as research
tools in the field of cell biology and pathology. Herein, we develop
an addressable double-bundle DNA tetrahedron with distinct modification
sites to load multiple functional components for efficient regulation
of gene expression. In our tailored nanoplatform, nucleic acid drugs
(antisense for gene therapy) and protein drugs (KillerRed for photodynamic
therapy) are precisely organized in the chemically well-defined DNA
tetrahedron. With the attachment of active targeting groups, this
functional DNA nanocarrier can efficiently penetrate into the cell
membrane and subsequently transport drugs to the target subcellular
organelles (mitochondrion and nucleus) for inducing synergistic cell
behavior regulation to start the endogenous apoptotic process. This
tailored DNA nanocarrier provides unprecedented opportunities for
intelligent drug delivery and cell biology research.
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Wu, Tiantian; Liu, Qing; Cao, Yuanwei; Tian, Run; Liu, Jianbing; Ding, Baoquan (2020). Multifunctional
Double-Bundle DNA Tetrahedron for
Efficient Regulation of Gene Expression. ACS Publications. Collection. https://doi.org/10.1021/acsami.0c08886