Mixed-Dimensional Heterostructure Material-Based SERS
for Trace Level Identification of Breast Cancer-Derived Exosomes
Posted on 2020-07-02 - 00:14
Raman
spectroscopy has capability for fingerprint molecular identification
with high sensitivity if weak Raman scattering signal can be enhanced
by several orders of magnitudes. Herein, we report a heterostructure-based
surface-enhanced Raman spectroscopy (SERS) platform using 2D graphene
oxide (GO) and 0D plasmonic gold nanostar (GNS), with capability of
Raman enhancement factor (EF) in the range of ∼1010 via light–matter and matter–matter interactions. The
current manuscript reveals huge Raman enhancement for heterostructure
materials occurring via both electromagnetic enhancement mechanism
though plasmonic GNS nanoparticle (EF ∼107) and
chemical enhancement mechanism through 2D-GO material (EF ∼102). Finite-difference time-domain (FDTD) simulation data and
experimental investigation indicate that GNS allows light to be concentrated
into nanoscale “hotspots” formed on the heterostructure
surface, which significantly enhanced Raman efficiency via a plasmon–exciton
light coupling process. Notably, we have shown that mixed-dimensional
heterostructure-based SERS can be used for tracking of cancer-derived
exosomes from triple-negative breast cancer and HER2(+) breast cancer
with a limit of detection (LOD) of 3.8 × 102 exosomes/mL
for TNBC-derived exosomes and 4.4 × 102 exosomes/mL
for HER2(+) breast cancer-derived exosomes.
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Pramanik, Avijit; Mayer, Justin; Patibandla, Shamily; Gates, Kaelin; Gao, Ye; Davis, Dalephine; et al. (2020). Mixed-Dimensional Heterostructure Material-Based SERS
for Trace Level Identification of Breast Cancer-Derived Exosomes. ACS Publications. Collection. https://doi.org/10.1021/acsomega.0c01441
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AUTHORS (8)
AP
Avijit Pramanik
JM
Justin Mayer
SP
Shamily Patibandla
KG
Kaelin Gates
YG
Ye Gao
DD
Dalephine Davis
RS
Ram Seshadri
PR
Paresh Chandra Ray
KEYWORDS
Mixed-Dimensional Heterostructure M...heterostructure surfacemixed-dimensional heterostructure-b...Raman efficiencyRaman enhancement factorchemical enhancement mechanismRaman enhancementEF2 D-GO materialheterostructure-based surface-enhan...FDTDheterostructure materialsTNBC-derived exosomessimulation dataFinite-difference time-domainHERelectromagnetic enhancement mechanismtriple-negative breast cancerLODTrace Level IdentificationBreast Cancer-Derived Exosomes Rama...2 D graphene oxidecancer-derived exosomesplasmonic GNS nanoparticle0 D plasmonic gold nanostar