Measurement and Correlation of Solubility of Theobromine,
Theophylline, and Caffeine in Water and Organic Solvents at Various
Temperatures
Posted on 2017-06-27 - 15:21
The
solubility of theobromine, theophylline, and caffeine in water
and five organic solvents including methanol, ethanol, 1-propanol,
ethyl acetate, and acetone was determined by a high performance liquid
chromatography method at T = (288.15 to 328.15) K
and atmospheric pressure. It was found that the solubility of theobromine,
theophylline, and caffeine in these solvents increased with increasing
temperature. The empirical Apelblat equation and universal quasichemical
model were used to correlate the experimental solubility. The results
showed that both models can satisfactorily correlate the solubility
data. The crystal forms of the solutes in equilibrium with the saturated
solution were analyzed using scanning electron microscopy and powder
X-ray diffraction.
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Zhong, Jialun; Tang, Ning; Asadzadeh, Behnaz; Yan, Weidong (2017). Measurement and Correlation of Solubility of Theobromine,
Theophylline, and Caffeine in Water and Organic Solvents at Various
Temperatures. ACS Publications. Collection. https://doi.org/10.1021/acs.jced.7b00065
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