Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry
Imaging of Lipids in Experimental Model of Traumatic Brain Injury
Detecting Acylcarnitines as Injury Related Markers
Posted on 2019-08-27 - 23:29
Identifying
new lipid markers linked to traumatic brain injury
(TBI) is of major importance in characterizing their central role
in the regeneration process and inflammatory response in such an injury
model. In the present study, an advanced lipidomics analysis using
high spectral resolution matrix-assisted laser desorption/ionization-mass
spectrometry imaging was performed on different brain regions in an
experimental rat model of moderate controlled cortical impact (CCI)
while considering different time points (1 day, 3 days, 7 days, and
10 days) assessing the acute and subacute phase after injury. Our
results revealed a new family of lipids, the acylcarnitines, as TBI-lipid
related markers, with maximum expression at 3 days after impact and
main colocalization within resident microglia of the brain. Furthermore,
our experiments highlighted the upregulation of these acylcarnitine
lipids, secreted by microglia, in the ipsilateral substantia
nigra, the main region in the brain affected in Parkinson’s
disease (PD).
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Mallah, Khalil; Quanico, Jusal; Raffo-Romero, Antonella; Cardon, Tristan; Aboulouard, Soulaimane; Devos, David; et al. (2019). Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry
Imaging of Lipids in Experimental Model of Traumatic Brain Injury
Detecting Acylcarnitines as Injury Related Markers. ACS Publications. Collection. https://doi.org/10.1021/acs.analchem.9b02633
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AUTHORS (10)
KM
Khalil Mallah
JQ
Jusal Quanico
AR
Antonella Raffo-Romero
TC
Tristan Cardon
SA
Soulaimane Aboulouard
DD
David Devos
FK
Firas Kobeissy
KZ
Kazem Zibara
MS
Michel Salzet
IF
Isabelle Fournier