Macroscopic Silicone Microchannel Matrix for Tailored Drug Release and Localized
Glioblastoma Therapy
Posted on 2020-04-22 - 19:48
Localized therapy
of the highly malignant brain tumor glioblastoma
multiforme (GBM) could help to drastically improve the treatment efficiency
and increase the patient’s median survival. Here, a macroscopic
PDMS matrix composed of interconnected microchannels for tailored
drug release and localized GBM therapy is introduced. Based on a simple
bottom-up fabrication method using a highly versatile sacrificial
template, the presented strategy solves the scaling problem associated
with the previously developed microchannel-based drug delivery systems,
which were limited to two dimensions due to the commonly employed
top-down microfabrication methods. Additionally, tailoring of the
microchannel density, the fraction of drug-releasing microchannels
and the macroscopic size of the drug delivery systems enabled precise
adjustment of the drug release kinetics for more than 10 days. As
demonstrated in a long-term GBM in vitro model, the
release kinetics of the exemplarily chosen GBM drug AT101 could be
tailored by variation of the microchannel density and the initial
drug concentration, leading to diffusion-controlled AT101 release.
Adapting a previously developed GBM treatment plan based on a sequential
stimulation with AT101, measured anti-tumorigenic effects of free versus PDMS-released AT101 were comparable in human GBM
cells and demonstrated efficient biological activity of PDMS-released
AT101.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Rasch, Florian; Schmitt, Christina; Saure, Lena M.; Meyer, Rieke; Adamski, Vivian; Dengiz, Duygu; et al. (2020). Macroscopic Silicone Microchannel Matrix for Tailored Drug Release and Localized
Glioblastoma Therapy. ACS Publications. Collection. https://doi.org/10.1021/acsbiomaterials.0c00094
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (14)
FR
Florian Rasch
CS
Christina Schmitt
LS
Lena M. Saure
RM
Rieke Meyer
VA
Vivian Adamski
DD
Duygu Dengiz
RS
Regina Scherließ
RL
Ralph Lucius
MS
Michael Synowitz
YM
Yogendra K. Mishra
KH
Kirsten Hattermann
RA
Rainer Adelung
JH
Janka Held-Feindt
FS
Fabian Schütt
KEYWORDS
Tailored Drug ReleaseGBM therapydrug releasedrug concentrationmacroscopic sizeGBM cellstop-down microfabrication methodsLocalized Glioblastoma Therapy Localized therapybottom-up fabrication methodMacroscopic Silicone Microchannel Matrixmicrochannel-based drug delivery systemsdrug-releasing microchannelsGBM treatment planGBM drugsequential stimulationdrug release kineticsanti-tumorigenic effectsrelease kinetics10 daystreatment efficiencymacroscopic PDMS matrixbrain tumor glioblastoma multiformedrug delivery systems101 release