Light-Addressable Potentiometric Sensors Using ZnO
Nanorods as the Sensor Substrate for Bioanalytical Applications
Version 2 2018-08-09, 23:43
Version 1 2018-07-06, 19:19
Posted on 2018-08-09 - 23:43
Light-addressable
potentiometric sensors (LAPS) are of great interest
in bioimaging applications such as the monitoring of concentrations
in microfluidic channels or the investigation of metabolic and signaling
events in living cells. By measuring the photocurrents at electrolyte–insulator–semiconductor
(EIS) and electrolyte–semiconductor structures, LAPS can produce
spatiotemporal images of chemical or biological analytes, electrical
potentials and impedance. However, its commercial applications are
often restricted by their limited AC photocurrents and resolution
of LAPS images. Herein, for the first time, the use of 1D semiconducting
oxides in the form of ZnO nanorods for LAPS imaging is explored to
solve this issue. A significantly increased AC photocurrent with enhanced
image resolution has been achieved based on ZnO nanorods, with a photocurrent
of 45.7 ± 0.1 nA at a light intensity of 0.05 mW, a lateral resolution
as low as 3.0 μm as demonstrated by images of a PMMA dot on
ZnO nanorods and a pH sensitivity of 53 mV/pH. The suitability of
the device for bioanalysis and bioimaging was demonstrated by monitoring
the degradation of a thin poly(ester amide) film with the enzyme α-chymotrypsin
using LAPS. This simple and robust route to fabricate LAPS substrates
with excellent performance would provide tremendous opportunities
for bioimaging.
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Tu, Ying; Ahmad, Norlaily; Briscoe, Joe; Zhang, De-Wen; Krause, Steffi (2018). Light-Addressable Potentiometric Sensors Using ZnO
Nanorods as the Sensor Substrate for Bioanalytical Applications. ACS Publications. Collection. https://doi.org/10.1021/acs.analchem.8b02244
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AUTHORS (5)
YT
Ying Tu
NA
Norlaily Ahmad
JB
Joe Briscoe
DZ
De-Wen Zhang
SK
Steffi Krause