Ligand-Driven and Full-Color-Tunable Fiber Source:
Toward Next-Generation Clinic Fiber-Endoscope Tomography with Cellular
Resolution
Version 3 2016-10-14, 18:51
Version 2 2016-10-14, 13:20
Version 1 2016-10-12, 16:36
Posted on 2016-10-31 - 00:00
In
many biomedical applications, broad full-color emission is important,
especially for wavelengths below 450 nm, which are difficult to cover
via supercontinuum generation. Single-crystalline-core sapphires with
defect-driven emissions have potential roles in the development of
next-generation broadband light sources because their defect centers
demonstrate multiple emission bands with tailored ligand fields. However,
the inability to realize high quantum yields with high crystallinity
by conventional methods hinders the applicability of ultra-broadband
emissions. Here, we present how an effective one-step fiber-drawing
process, followed by a simple and controllable thermal treatment,
enables a low-loss, full-color, and crystal fiber-based generation
with substantial color variability. The broad spectrum extends from
330 nm, which is over 50 nm further into the UV region than that in
previously reported results. The predicted submicrometer spatial resolutions
demonstrate that the defect–ligand fields are potentially beneficial
for achieving in vivo cellular tomography. It is also noteworthy that the
efficiency of the milliwatt-level full-color generation, with an optical-to-optical
efficiency of nearly 5%, is the highest among that of the existing
active waveguide schemes. In addition, direct evidence from high-resolution
transmission electron microscopy together with electron energy loss
spectroscopy and crystal-field ligands reveals an excellent crystalline
core, atomically defined core/cladding interfacial roughness, and
significant enhancements in new laser-induced electronic defect levels.
Our work suggests an inexpensive, facile, and highly scalable route
toward achieving cellular-resolution tomographic imaging and represents
an important step in the development of endoscope-compatible diagnostic
devices.
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Lai, Chien-Chih; Lo, Chia-Yao; Hsieh, Tsung-Hsun; Tsai, Wan-Shao; Nguyen, Duc Huy; Ma, Yuan-Ron (2016). Ligand-Driven and Full-Color-Tunable Fiber Source:
Toward Next-Generation Clinic Fiber-Endoscope Tomography with Cellular
Resolution. ACS Publications. Collection. https://doi.org/10.1021/acsomega.6b00146
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AUTHORS (6)
CL
Chien-Chih Lai
CL
Chia-Yao Lo
TH
Tsung-Hsun Hsieh
WT
Wan-Shao Tsai
DN
Duc Huy Nguyen
YM
Yuan-Ron Ma
KEYWORDS
fiber-drawing processdefect centersSingle-crystalline-core sapphiresNext-Generation Clinic Fiber-Endoscope TomographyCellular Resolution50 nmcolor variabilitycellular-resolution tomographic imagingsupercontinuum generationnext-generation broadband light sourcesUV regionoptical-to-optical efficiencyFull-Color-Tunable Fiber Sourcemilliwatt-level full-color generationemission bandsquantum yieldscrystal-field ligands330 nmultra-broadband emissionstransmission electron microscopycrystal fiber-based generation450 nmligand fieldsdefect levelsdefect-driven emissionsscalable routefull-color emissionwaveguide schemeselectron energy loss spectroscopy