Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos
Posted on 2018-07-13 - 15:55
Recent advances in intravital video microscopy have allowed the visualization of leukocyte behavior in vivo, revealing unprecedented spatiotemporal dynamics of immune cell interaction. However, state-of-the-art software and methods for automatically measuring cell migration exhibit limitations in tracking the position of leukocytes over time. Challenges arise both from the complex migration patterns of these cells and from the experimental artifacts introduced during image acquisition. Additionally, the development of novel tracking tools is hampered by the lack of a sound ground truth for algorithm validation and benchmarking. Therefore, the objective of this work was to create a database, namely LTDB, with a significant number of manually tracked leukocytes. Broad experimental conditions, sites of imaging, types of immune cells and challenging case studies were included to foster the development of robust computer vision techniques for imaging-based immunological research. Lastly, LTDB represents a step towards the unravelling of biological mechanisms by video data mining in systems biology.
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Pizzagalli, Diego Ulisse; Farsakoglu, Yagmur; Palomino-Segura, Miguel; Palladino, Elisa; Sintes, Jordi; Marangoni, Francesco; et al. (2018). Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3827890.v1
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AUTHORS (15)
DP
Diego Ulisse Pizzagalli
YF
Yagmur Farsakoglu
MP
Miguel Palomino-Segura
EP
Elisa Palladino
JS
Jordi Sintes
FM
Francesco Marangoni
TM
Thorsten Mempel
WK
Wan Hon Koh
TM
Thomas T. Murooka
FT
Flavian Thelen
JS
Jens Volker Stein
GP
Giuseppe Pozzi
MT
Marcus Thelen
RK
Rolf Krause
SG
Santiago Fernandez Gonzalez