In Situ Growing Triethanolamine-Functionalized Metal–Organic
Frameworks on Two-Dimensional Carbon Nanosheets for Electrochemiluminescent Immunoassay
Posted on 2019-09-06 - 14:46
A facile strategy
for in situ growing triethanolamine (TEOA)-functionalized
metal–organic framework (TEOA@MOF) on the two-dimensional graphene
oxide (GO) or g-C3N4 nanosheets via the self-assembly
technique was introduced. In this method, Zn2+ was first
attached on the carbon nanosheets by electrostatic interaction; then,
trimesic acid (H3btc) acted as the complex agent and TEOA
as a base for the deprotonation of H3btc and a template,
which leads to in situ growing the MOF on the carbon nanosheets obtaining
a sandwich-like structure. Different types of surface analysis techniques
were employed to characterize the GO-TEOA@MOFs and g-C3N4-TEOA@MOFs nanomaterials fabricated. The GO-TEOA@MOFs
or g-C3N4-TEOA@MOFs nanomaterial-modified electrode
brings out obviously enhanced electrochemiluminescence (ECL) behaviors
due to numerous TEOA in the framework structures. Specifically, both
TEOA and GO can serve as the co-reactants for the ECL system of Ru(bpy)32+ and have the synergic effect of enhancing the
signal. Based on the GO-TEOA@MOFs modified electrodes, we developed
a sensitive and rapid label-free ECL immunoassay strategy for human
copeptin, and the linear range was 5 pg mL–1 to
500 ng mL–1 as well as the limit of detection was
360 fg mL–1. This work exhibits excellent specificity
and good stability of the prepared immunosensor in the practical sample
determination, demonstrating it can serve as a very promising method
for the clinical diagnostics of acute myocardial infarction disease.
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Qin, Xiaoli; Dong, Yifan; Wang, Minghan; Zhu, Zhiwei; Li, Meixian; Yang, Di; et al. (2019). In Situ Growing Triethanolamine-Functionalized Metal–Organic
Frameworks on Two-Dimensional Carbon Nanosheets for Electrochemiluminescent Immunoassay. ACS Publications. Collection. https://doi.org/10.1021/acssensors.9b00914
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AUTHORS (7)
XQ
Xiaoli Qin
YD
Yifan Dong
MW
Minghan Wang
ZZ
Zhiwei Zhu
ML
Meixian Li
DY
Di Yang
YS
Yuanhua Shao