Improved Admixture Vaccine of Fentanyl and Heroin
Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated
Heroin
Posted on 2018-09-20 - 18:03
Fentanyl
and its derivatives have become pervasive contaminants
in the U.S. heroin supply. Previously, we reported a proof-of-concept
vaccine designed to combat against heroin contaminated with fentanyl.
Herein, we optimized the admixture vaccine and found that it surpassed
the individual vaccines in every antinociceptive test, including a
10% fentanyl to heroin formulation. It is anticipated that other co-occurring
drug abuse disorders may also be examined with admixture vaccines.
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Hwang, Candy
S.; Smith, Lauren C.; Natori, Yoshihiro; Ellis, Beverly; Zhou, Bin; Janda, Kim D. (2018). Improved Admixture Vaccine of Fentanyl and Heroin
Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated
Heroin. ACS Publications. Collection. https://doi.org/10.1021/acsomega.8b01478
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AUTHORS (6)
CH
Candy
S. Hwang
LS
Lauren C. Smith
YN
Yoshihiro Natori
BE
Beverly Ellis
BZ
Bin Zhou
KJ
Kim D. Janda