Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

Posted on 2018-09-18 - 05:00
Abstract Background Classification of COPD is usually based on the severity of airflow, which may not sensitively differentiate subpopulations. Using a multiscale imaging-based cluster analysis (MICA), we aim to identify subpopulations for current smokers with COPD. Methods Among the SPIROMICS subjects, we analyzed computed tomography images at total lung capacity (TLC) and residual volume (RV) of 284 current smokers. Functional variables were derived from registration of TLC and RV images, e.g. functional small airways disease (fSAD%). Structural variables were assessed at TLC images, e.g. emphysema and airway wall thickness and diameter. We employed an unsupervised method for clustering. Results Four clusters were identified. Cluster 1 had relatively normal airway structures; Cluster 2 had an increase of fSAD% and wall thickness; Cluster 3 exhibited a further increase of fSAD% but a decrease of wall thickness and airway diameter; Cluster 4 had a significant increase of fSAD% and emphysema. Clinically, Cluster 1 showed normal FEV1/FVC and low exacerbations. Cluster 4 showed relatively low FEV1/FVC and high exacerbations. While Cluster 2 and Cluster 3 showed similar exacerbations, Cluster 2 had the highest BMI among all clusters. Conclusions Association of imaging-based clusters with existing clinical metrics suggests the sensitivity of MICA in differentiating subpopulations.

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Haghighi, Babak; Choi, Sanghun; Choi, Jiwoong; Hoffman, Eric; Comellas, Alejandro; Newell, John; et al. (2018): Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4236602.v1
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Respiratory Research

AUTHORS (20)

Babak Haghighi
Sanghun Choi
Jiwoong Choi
Eric Hoffman
Alejandro Comellas
John Newell
R. Graham Barr
Eugene Bleecker
Christopher Cooper
David Couper
Mei Han
Nadia Hansel
Richard Kanner
Ella Kazerooni
Eric Kleerup
Fernando Martinez
Wanda O’Neal
Stephen Rennard
Prescott Woodruff
Ching-Long Lin
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