Hybrid Composite of Silver Nanoparticle–Porous
Silicon Microparticles as an Image-Guided Localization Agent for Computed
Tomography Scan of the Lungs
Posted on 2020-06-27 - 17:13
A hybrid composite
of silver nanoparticles (AgNPs) and porous silicon
microparticles (pSiMPs) was developed and applied for the computed
tomography (CT) scanning of the lungs as an image-guided localization
agent. We confirmed the grafting of AgNPs on oxidized pSiMPs template
using various analytical equipment, including a scanning electron
microscope (SEM), Fourier transform infrared (FTIR) spectroscopy,
X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy
(EDS). The hybrid composite showed a high CT contrast intensity (>1000
HU) that enabled us to produce and view images of the lungs. In addition,
it showed the ability to maintain a strong CT signal at the injected
area of the rabbit’s lungs, up to an hour, without spreading.
The lack of toxicity and immune response indicated that the composite
could be fully utilized as a new image-guided localization agent of
CT scans for lung cancer surgery.
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Lee, Eun Mi; Lee, Jiyeon; Kim, Yejin; Yi, Kyung Sik; Cho, Janggeun; Kim, Jaehoon; et al. (2020). Hybrid Composite of Silver Nanoparticle–Porous
Silicon Microparticles as an Image-Guided Localization Agent for Computed
Tomography Scan of the Lungs. ACS Publications. Collection. https://doi.org/10.1021/acsbiomaterials.0c00611
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AUTHORS (18)
EL
Eun Mi Lee
JL
Jiyeon Lee
YK
Yejin Kim
KY
Kyung Sik Yi
JC
Janggeun Cho
JK
Jaehoon Kim
JA
Jong Min An
DL
Dahae Lee
SK
Sung Joon Kim
EA
Eunkyung An
YH
Yoo Jin Hong
HJ
Hyejung Jo
SL
Seo Hyeon Lee
YJ
Yuna Jung
CC
Chi-Hoon Choi
JK
Jae Seung Kang
JH
Jin Hur
DK
Dokyoung Kim
KEYWORDS
HUpSiMPs templatesilicon microparticlesComputed Tomography Scanlung cancer surgeryimage-guided localization agentX-ray diffractionFTIRview imagesSEMHybrid Compositesilver nanoparticlesXRDscanning electron microscopeenergy-dispersive X-ray spectroscopyCT scansImage-Guided Localization AgentCT signalEDSAgNP