Helical Inclusions in Phospholipid Membranes: Lipid
Adaptation and Chiral Order
Posted on 2019-09-09 - 14:50
The
lipid bilayer is a flexible matrix that is able to adapt in
response to the perturbation induced by inclusions, such as peptides
and proteins. Here we use molecular dynamics simulations with a coarse-grained
model to investigate the effect of a helical inclusion on a lipid
bilayer in the liquid disordered phase. We show that the helical inclusion
induces a collective tilt of acyl chains, with a small, yet unambiguous
difference between a right- and a left-handed inclusion. This behavior
is rationalized using the elastic continuum theory: The magnitude
of the chiral (twist) deformation of the bilayer is determined by
the interaction at the lipid/inclusion interface, and the decay length
is controlled by the elastic properties of the bilayer. The lipid
reorganization can thus be identified as a generic mechanism that,
together with specific interactions, contributes to chiral recognition
in phospholipid bilayers. An enhanced response is expected in highly
ordered environments, such as rafts in biomembranes, with a potential
impact on membrane-mediated interactions between inclusions.
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Pannuzzo, Martina; Szała, Beata; Raciti, Domenica; Raudino, Antonio; Ferrarini, Alberta (2019). Helical Inclusions in Phospholipid Membranes: Lipid
Adaptation and Chiral Order. ACS Publications. Collection. https://doi.org/10.1021/acs.jpclett.9b02252