Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry
Posted on 2017-07-14 - 05:00
Abstract Background The INSIGHTS-IPF registry provides one of the largest data sets of clinical data and self-reported patient related outcomes including health related quality of life (QoL) on patients with idiopathic pulmonary fibrosis (IPF). We aimed to describe associations of various QoL instruments between each other and with patient characteristics at baseline. Methods Six hundred twenty-three IPF patients with available QoL data (St George’s Respiratory Questionnaire SGRQ, UCSD Shortness-of-Breath Questionnaire SoB, EuroQol visual analogue scale and index EQ-5D, Well-being Index WHO-5) were analysed. Mean age was 69.6 ± 8.7 years, 77% were males, mean disease duration 2.0 ± 3.3 years, FVC pred was 67.5 ± 17.8%, DLCO pred 35.6 ± 17%. Results Mean points were SGRQ total 48.3, UCSD SoB 47.8, EQ-5D VAS 66.8, and WHO-5 13.9. These instruments had a high or very high correlation (exception WHO-5 to EQ-5D VAS with moderate correlation). On bivariate analysis, QoL by SGRQ total was statistically significantly associated with clinical symptoms (NYHA; p < 0.001), number of comorbidities (p < 0.05), hospitalisation rate (p < 0.01) and disease severity (as measured by GAP score, CPI, FVC and 6-min walk test; p < 0.05 each). Multivariate analyses showed a significant association between QoL (by SGRQ total) and IPF duration, FVC, age, NYHA class and indication for long-term oxygen treatment. Conclusions Overall, IPF patients under real-life conditions have lower QoL compared to those in clinical studies. There is a meaningful relationship between QoL and various patient characteristics. Trial registration The INSIGHTS-IPF registry is registered at Clinicaltrials.gov ( NCT01695408 ).
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Kreuter, Michael; Swigris, Jeff; Pittrow, David; Geier, Silke; Klotsche, Jens; Prasse, Antje; et al. (2017). Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3827596.v1
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AUTHORS (25)
MK
Michael Kreuter
JS
Jeff Swigris
DP
David Pittrow
SG
Silke Geier
JK
Jens Klotsche
AP
Antje Prasse
HW
Hubert Wirtz
DK
Dirk Koschel
SA
Stefan Andreas
MC
Martin Claussen
CG
Christian Grohé
HW
Henrike Wilkens
LH
Lars Hagmeyer
DS
Dirk Skowasch
JM
Joachim Meyer
JK
Joachim Kirschner
SG
Sven Gläser
FH
Felix Herth
TW
Tobias Welte
CN
Claus Neurohr