Fusaristatin C, a Cyclic Lipodepsipeptide from Pithomyces sp. RKDO 1698
Posted on 2018-12-07 - 20:49
A new cyclic lipodepsipeptide, fusaristatin
C (1),
was obtained from the fungus Pithomyces sp. RKDO
1698, which was isolated from the Caribbean octocoral Eunicea
fusca. The 2D structure of fusaristatin C was elucidated
using NMR spectroscopy and mass spectrometry, while the absolute configuration
of the sole chiral amino acid residue (l-serine) was determined
using Marfey’s method. 3-Hydroxy-2,11-dimethyltetradecanoic
acid (HDMT) was cleaved from 1, and the absolute configuration
at the C-3 position was determined using Mosher’s ester analysis.
Subsequent J-based configuration analysis of 1 allowed for assignment of the C-2 configuration. Fusaristatin
C exhibited no antimicrobial activity or cytotoxicity.
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MacIntyre, Logan
W.; Marchbank, Douglas H.; Correa, Hebelin; Kerr, Russell G. (2018). Fusaristatin C, a Cyclic Lipodepsipeptide from Pithomyces sp. RKDO 1698. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.8b00787
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AUTHORS (4)
LM
Logan
W. MacIntyre
DM
Douglas H. Marchbank
HC
Hebelin Correa
RK
Russell G. Kerr