Formulation
of Gelled Non-toxic Bicontinuous Microemulsions
Stabilized by Highly Efficient Alkanoyl Methylglucamides
Posted on 2020-10-16 - 17:45
Gelled non-toxic bicontinuous microemulsions
have a great potential
for transdermal drug delivery as the microemulsion facilitates the
solubilization of both hydrophilic and hydrophobic drugs, while the
gel network provides mechanical stability and thus an easy application
on the skin. In our previous study, we formulated a gelled non-toxic
bicontinuous microemulsion: we gelled the system H2O–isopropyl
myristate (IPM)–Plantacare 1200 UP (C12G1.4)–1,2-octanediol with the low molecular weight organogelator 1,3:2,4-dibenzylidene-d-sorbitol (DBS). However, a large amount of Plantacare 1200
UP (12 wt %) is needed to form a bicontinuous microemulsion. To solve
this problem, we studied a new class of surfactants, namely, alkanoyl
methylglucamides (MEGA), which have been rarely used for the formulation
of microemulsions. The phase behavior of microemulsions stabilized
by MEGA-8/10, MEGA-12/14-PC, and MEGA-12/14-HC was compared with that
of systems stabilized by alkyl polyglucosides. We found that even
with 2 wt % MEGA-12/14-HC, a bicontinuous microemulsion can be formed,
which is 1/6 of the amount of Plantacare 1200 UP. The bicontinuous
microstructure of the non-toxic microemulsion H2O–IPM–MEGA-12/14-HC–1,2-octanediol
was confirmed by small-angle neutron scattering. Furthermore, the
phase boundaries remained unchanged when gelled by DBS. The rheological
properties of the gel were studied by oscillatory shear rheometry.
Finally, freeze-fracture electron microscopy images show the coexistence
of gel fibers and bicontinuous oil and water domains. These results
suggest that the new gelled non-toxic bicontinuous microemulsion is
an orthogonal self-assembled system.
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Peng, Ke; Preisig, Natalie; Sottmann, Thomas; Stubenrauch, Cosima (2020). Formulation
of Gelled Non-toxic Bicontinuous Microemulsions
Stabilized by Highly Efficient Alkanoyl Methylglucamides. ACS Publications. Collection. https://doi.org/10.1021/acs.langmuir.0c02314
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AUTHORS (4)
KP
Ke Peng
NP
Natalie Preisig
TS
Thomas Sottmann
CS
Cosima Stubenrauch