Folding Kinetics of Single Human Telomeric G‑Quadruplex
Affected by Cisplatin

Wang, Peng-Ye

Folding Kinetics of Single Human Telomeric G‑Quadruplex Affected by Cisplatin

Posted on 2016-08-03 - 00:00

G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadruplex, implying that cisplatin actually may also target G-quadruplex. In this work, we employed magnetic tweezers to investigate the influence of cisplatin on the folding kinetics of single human telomeric G-quadruplex. It was revealed that cisplatin and G-quadruplex interact in two different and competitive ways that depend on cisplatin concentration.

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Ju, Hai-Peng; Wang, Yi-Zhou; You, Jing; Hou, Xi-Miao; Xi, Xu-Guang; Dou, Shuo-Xing; et al. (2016). Folding Kinetics of Single Human Telomeric G‑Quadruplex Affected by Cisplatin. ACS Publications. Collection. https://doi.org/10.1021/acsomega.6b00044

https://doi.org/10.1021/acsomega.6b00044

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