Far-Red and Near-Infrared Seminaphthofluorophores
for Targeted Pancreatic Cancer Imaging
Posted on 2017-01-20 - 09:14
Molecular probes
that selectively highlight pancreatic cancer (PC)
tissue have the potential to improve pancreatic ductal adenocarcinoma
(PDAC) margin assessment through the selective highlighting of individual
PC cells. Herein, we report a simple and unique family of systematically
modified red and near-infrared fluorescent probes that exhibit a field-effect-derived
redshift. Two of thirteen probes distributed to the normal mouse pancreas
following systemic administration. One selectively accumulated in
genetically modified mouse models of PDAC. The probe exhibited intracellular
accumulation and enabled visualization of four levels of the structure,
including the whole organ, resected tissue, individual cells, and
subcellular organelles. In contrast to the small-molecule probes reported
previously, it possesses an inherent affinity toward PDAC cells and
thus does not require conjugation to any targeting agent. The fluorescent
probe can thus promote new strategies not only for precision image-guided
surgery, but also for PC detection, monitoring of therapeutic outcomes,
and basic research.
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Wang, Lei; Barth, Connor W.; Sibrian-Vazquez, Martha; Escobedo, Jorge O.; Lowry, Mark; Muschler, John; et al. (2017). Far-Red and Near-Infrared Seminaphthofluorophores
for Targeted Pancreatic Cancer Imaging. ACS Publications. Collection. https://doi.org/10.1021/acsomega.6b00403
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AUTHORS (9)
LW
Lei Wang
CB
Connor W. Barth
MS
Martha Sibrian-Vazquez
JE
Jorge O. Escobedo
ML
Mark Lowry
JM
John Muschler
HL
Haiyan Li
SL
Summer L. Gibbs
RS
Robert M. Strongin
KEYWORDS
PDAC cellsfield-effect-derived redshiftintracellular accumulationpancreatic cancermouse pancreaspancreatic ductal adenocarcinomamouse modelsprecision image-guided surgeryPC cellssubcellular organellesNear-Infrared Seminaphthofluorophoresmargin assessmentTargeted Pancreatic Cancer Imaging Molecular probesresected tissuePC detectionsmall-molecule probes