Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings
for Building Eight-Membered Sultam/Lactam Frameworks
Posted on 2020-07-02 - 03:03
Described
herein is an unusual Cp*CyRh(III)-catalyzed
intramolecular site-specific aryl C–H annulation, a highly
chemoselective protocol providing direct access to eight-membered
sultams/lactams with broad substrate/functional group tolerance. Experimental
and computational studies reveal that such a transformation involves
a unique PivOH-assisted aryl C–H activation/alkene insertion/β-H
elimination/hydrogen-transfer process involving the Rh(III)–hydride
species as the active intermediate with the concomitant release of
H2 as the major byproduct, thus enabling the developed
Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical
features.
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Li, Liping; Gao, Hui; Sun, Ming; Zhou, Zhi; Yi, Wei (2020). Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings
for Building Eight-Membered Sultam/Lactam Frameworks. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c01823
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