Enhancing the Antibacterial Activity of Light-Activated
Surfaces Containing Crystal Violet and ZnO Nanoparticles: Investigation
of Nanoparticle Size, Capping Ligand, and Dopants
Version 2 2016-09-06, 11:33
Version 1 2016-09-05, 08:13
Posted on 2016-09-30 - 00:00
Healthcare-associated
infections pose a serious risk for patients,
staff, and visitors and are a severe burden on the National Health
Service, costing at least £1 billion annually. Antimicrobial
surfaces significantly contribute toward reducing the incidence of
infections as they prevent bacterial adhesion and cause bacterial
cell death. Using a simple, easily upscalable swell–encapsulation–shrink
method, novel antimicrobial surfaces have been developed by incorporating
metal oxide nanoparticles (NPs) and crystal violet (CV) dye into medical-grade
polyurethane sheets. This study compares the bactericidal effects
of polyurethane incorporating ZnO, Mg-doped ZnO, and MgO. All metal
oxide NPs are well defined, with average diameters ranging from 2
to 18 nm. These materials demonstrate potent bactericidal activity
when tested against clinically relevant bacteria such as Escherichia coli and Staphylococcus
aureus. Additionally, these composites are tested
against an epidemic strain of methicillin-resistant Staphylococcus aureus (MRSA) that is rife in hospitals
throughout the UK. Furthermore, we have tested these materials using
a low light intensity (∼500 lx), similar to that present in
many clinical environments. The highest activity is achieved from
polymer composites incorporating CV and ∼3 nm ZnO NPs, and
the different performances of the metal oxides have been discussed.
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Sehmi, Sandeep
K.; Noimark, Sacha; Pike, Sebastian
D.; Bear, Joseph C.; Peveler, William J.; Williams, Charlotte K.; et al. (2016). Enhancing the Antibacterial Activity of Light-Activated
Surfaces Containing Crystal Violet and ZnO Nanoparticles: Investigation
of Nanoparticle Size, Capping Ligand, and Dopants. ACS Publications. Collection. https://doi.org/10.1021/acsomega.6b00017
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AUTHORS (10)
SS
Sandeep
K. Sehmi
SN
Sacha Noimark
SP
Sebastian
D. Pike
JB
Joseph C. Bear
WP
William J. Peveler
CW
Charlotte K. Williams
MS
Milo S. P. Shaffer
EA
Elaine Allan
IP
Ivan P. Parkin
AM
Alexander J. MacRobert
KEYWORDS
methicillin-resistant Staphylococcus aureusmetal oxide NPsbactericidal effectsbactericidal activitymaterialnovel antimicrobial surfacesmedical-grade polyurethane sheetsMg-doped ZnO18 nmZnO NanoparticlesUKAntimicrobial surfacespolymer compositesEscherichia colicrystal violetAntibacterial ActivityLight-Activated Surfaces Containing Crystal VioletCVNational Health Servicemetal oxidesmetal oxide nanoparticlesStaphylococcus aureusMRSANanoparticle SizeDopants Healthcare-associated infectionscell deathepidemic strain