Dynamic
Origin of Chirality Transfer between Chiral
Surface and Achiral Ligand in Au38 Clusters
Version 4 2020-06-06, 13:29
Version 3 2019-07-15, 17:36
Version 2 2019-06-14, 14:46
Version 1 2019-06-14, 14:45
Posted on 2020-06-06 - 13:29
The
transfer of chirality between nanomolecules is at the core
of several applications in chiral technology such as sensing and catalysis.
However, the origin of this phenomenon and how exactly nanoscale objects
transfer chirality to molecules in their vicinity remain largely obscure.
Here, we show that the transfer of chirality for the intrinsically
chiral gold cluster Au38(SR)24 is site dependent;
that is, it differs depending on the ligand-binding sites. This is
closely related to the dynamic nature of the ligands on the cluster
surface. Using a combination of NMR techniques and molecular dynamics
simulations, we could assign the four symmetry-unique ligands on the
cluster. The study reveals largely different conformational dynamics
of the bound ligands, explaining the diverse diastereotopicities observed
for the CH2 protons of the ligands. Although chirality
is a structural property, our study reveals the importance of dynamics
for the transfer of chirality.
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Riccardi, Laura; De Biasi, Federico; De Vivo, Marco; Bürgi, Thomas; Rastrelli, Federico; Salassa, Giovanni (2019). Dynamic
Origin of Chirality Transfer between Chiral
Surface and Achiral Ligand in Au38 Clusters. ACS Publications. Collection. https://doi.org/10.1021/acsnano.9b02552
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AUTHORS (6)
LR
Laura Riccardi
FD
Federico De Biasi
MD
Marco De Vivo
TB
Thomas Bürgi
FR
Federico Rastrelli
GS
Giovanni Salassa