Development of a Negative-Biased Zwitterionic Polypeptide-Based
Nanodrug Vehicle for pH-Triggered Cellular Uptake and Accelerated
Drug Release
Posted on 2020-06-18 - 14:44
Albumin mimics could
be an attractive platform for nanodrug carriers
through systematic administration because of high safety and plentiful
properties to be adjusted for a high drug efficacy, such as pH-triggered
targeting cellular uptake and drug release. In this work, negative-biased
zwitterionic nanodrug carriers based on zwitterionic polypeptide chains
that mimic albumin were prepared, which have an outermost layer of
zwitterionic glutamic acid (E) and lysine (K) pairs with a small amount
of aspartic acid (D) to adjust the overall ζ potential. On the
other hand, doxorubicin (Dox) was encapsulated in a hydrophobic core
by 11-maleimidoundecanoic acid covalently linked with additional cysteine
(C) residues on the polypeptide. The results show that the negative-biased
zwitterionic nanodrug carriers can sensitively enhance the cellular
uptake in responding to a pH change from 7.4 to 6.7 without reversing
the ζ potential to a positive charge, leading to accelerating
the Dox release rate in a slightly acidic environment through the
polypeptide secondary structure change. Moreover, the anionic nanodrug
carrier can also be easily enzymatically digested by trypsin for quick
drug release. In short, this negative-biased zwitterionic nanodrug
delivery vector could be an ideal candidate for a safer tumor inhibition
with a high efficacy than conventional synthetic polymer-based ones.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Trital, Ashish; Xue, Weili; Chen, Shengfu (2020). Development of a Negative-Biased Zwitterionic Polypeptide-Based
Nanodrug Vehicle for pH-Triggered Cellular Uptake and Accelerated
Drug Release. ACS Publications. Collection. https://doi.org/10.1021/acs.langmuir.0c00166
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
AUTHORS (3)
AT
Ashish Trital
WX
Weili Xue
SC
Shengfu Chen
KEYWORDS
Drug Release Albumin mimicsuptakenegative-biased zwitterionic nanodrug delivery vectorDox release ratezwitterionic polypeptide chains11- maleimidoundecanoic acid covalentlyNegative-Biased Zwitterionic Polypeptide-Based Nanodrug Vehiclenegative-biased zwitterionic nanodrug carriersefficacypH-Triggered Cellular Uptakedrug release