Dehydrosulfurative C–N Cross-Coupling and Concomitant
Oxidative Dehydrogenation for One-Step Synthesis of 2‑Aryl(alkyl)aminopyrimidines
from 3,4-Dihydropyrimidin‑1H‑2-thiones

Sohn, Jeong-Hun

Dehydrosulfurative C–N Cross-Coupling and Concomitant Oxidative Dehydrogenation for One-Step Synthesis of 2‑Aryl(alkyl)aminopyrimidines from 3,4-Dihydropyrimidin‑1H‑2-thiones

Version 2 2016-10-03, 15:52

Version 1 2016-09-28, 16:53

Posted on 2016-09-28 - 00:00

A method for the synthesis of 2-aryl(alkyl)aminopyrimidines from readily available 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) via dehydrosulfurative C–N cross-coupling and concomitant oxidative dehydrogenation under a Pd/Cu catalytic system is described. This reaction protocol provides unprecedented diversity of fully substituted 2-aryl(alkyl)aminopyrimidines in a single step from a wide range of DHPMs and amine coupling partners.

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Phan, Nguyen Huu Trong; Kim, Hyeji; Shin, Hyunik; Lee, Hee-Seung; Sohn, Jeong-Hun (2016). Dehydrosulfurative C–N Cross-Coupling and Concomitant Oxidative Dehydrogenation for One-Step Synthesis of 2‑Aryl(alkyl)aminopyrimidines from 3,4-Dihydropyrimidin‑1H‑2-thiones. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.6b02617

https://doi.org/10.1021/acs.orglett.6b02617

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