Dataset for: MAP6 interacts with Tctex1 and Cav2.2/N-type calcium channels to regulate calcium signaling in neurons
Posted on 2017-11-22 - 10:57 authored by Wiley Admin
MAP6 proteins were first described as microtubule-stabilizing agents, whose properties were thought to be essential for neuronal development and maintenance of complex neuronal networks. However, deletion of all MAP6 isoforms in MAP6 KO mice does not lead to dramatic morphological aberrations of the brain but rather to alterations in multiple
neurotransmissions and severe behavioral impairments. A search for protein partners of MAP6 proteins identified Tctex1 - a dynein light chain with multiple non-microtubule-related functions. The involvement of Tctex1 in calcium signaling led to investigate it in MAP6 KO neurons. In the present study, we show that functional Cav2.2/N-type calcium channels are deficient in MAP6 KO neurons, due to improper location. We also show that MAP6 proteins interact directly with both Tctex1 and the C-terminus of Cav2.2/N-type calcium channels. A balance of these two interactions seems to be crucial for MAP6 to modulate calcium signaling in neurons.
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Brocard, Jacques; DUFOUR, FABRICE; GORY-FAURE, SYLVIE; ARNOULT, CHRISTOPHE; Bosc, Christophe; DENARIER, ERIC; et al. (2017). Dataset for: MAP6 interacts with Tctex1 and Cav2.2/N-type calcium channels to regulate calcium signaling in neurons. Wiley. Collection. https://doi.org/10.6084/m9.figshare.c.3915811.v1
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AUTHORS (11)
JB
Jacques Brocard
FD
FABRICE DUFOUR
SG
SYLVIE GORY-FAURE
CA
CHRISTOPHE ARNOULT
CB
Christophe Bosc
ED
ERIC DENARIER
LP
LETICIA PERIS
YS
YASMINA SAOUDI
MD
MICHEL DE WAARD
AA
Annie Andrieux