DNA Origami Nanoantennas with over 5000-fold Fluorescence
Enhancement and Single-Molecule Detection at 25 μM
Posted on 2015-12-09 - 00:00
Optical nanoantennas are known to
focus freely propagating light and reversely to mediate the emission
of a light source located at the nanoantenna hotspot. These effects
were previously exploited for fluorescence enhancement and single-molecule
detection at elevated concentrations. We present a new generation
of self-assembled DNA origami based optical nanoantennas with improved
robustness, reduced interparticle distance, and optimized quantum-yield
improvement to achieve more than 5000-fold fluorescence enhancement
and single-molecule detection at 25 μM background fluorophore
concentration. Besides outperforming lithographic optical antennas,
DNA origami nanoantennas are additionally capable of incorporating
single emitters or biomolecular assays at the antenna hotspot.
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Puchkova, Anastasiya; Vietz, Carolin; Pibiri, Enrico; Wünsch, Bettina; Paz, María Sanz; Acuna, Guillermo P.; et al. (2016). DNA Origami Nanoantennas with over 5000-fold Fluorescence
Enhancement and Single-Molecule Detection at 25 μM. ACS Publications. Collection. https://doi.org/10.1021/acs.nanolett.5b04045
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AUTHORS (7)
AP
Anastasiya Puchkova
CV
Carolin Vietz
EP
Enrico Pibiri
BW
Bettina Wünsch
MP
María Sanz Paz
GA
Guillermo P. Acuna
PT
Philip Tinnefeld