Cyclodextrin-Functionalized Fiber Yarns Spun from
Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture
in Aqueous Matrices
Version 2 2018-08-15, 21:13
Version 1 2018-02-02, 19:06
Posted on 2018-08-15 - 21:13
A wood
based yarn platform for capturing pharmaceutical molecules
from water was developed. Cellulose fiber yarns were modified with
cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2),
a synthetic estrogen hormone used as contraceptive, from water was
tested. The yarns were prepared by spinning a deep eutectic solution
(DES) of cellulose in choline chloride-urea. Despite their high porosity
and water sorption capacity (5 g/g), the spun fiber yarns displayed
high wet strength, up to 60% of that recorded in dry condition (128
MPa with 17% strain at break). Cyclodextrin irreversible attachment
on the yarns was achieved with adsorbed chitosan and the conjugation
reactions and capture of EE2 by the cyclodextrin-modified cellulose
were confirmed via online detection with Surface Plasmon Resonance
(SPR). The facile synthesis of the bioactive yarns and EE2 binding
capacity from aqueous matrices (as high as 2.5 mg/g) indicate excellent
prospects for inexpensive platforms in disposable affinity filtration.
The study presents a strategy to produce a wood fiber based yarn to
be used as a platform for human and veterinary pharmaceutical hormone
capture.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Orelma, Hannes; Virtanen, Tommi; Spoljaric, Steven; Lehmonen, Jani; Seppälä, Jukka; Rojas, Orlando J.; et al. (2018). Cyclodextrin-Functionalized Fiber Yarns Spun from
Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture
in Aqueous Matrices. ACS Publications. Collection. https://doi.org/10.1021/acs.biomac.7b01765
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (7)
HO
Hannes Orelma
TV
Tommi Virtanen
SS
Steven Spoljaric
JL
Jani Lehmonen
JS
Jukka Seppälä
OR
Orlando J. Rojas
AH
Ali Harlin
KEYWORDS
17α- ethinyl estradiolEE 2 binding capacityAqueous Matricesaffinity filtrationestrogen hormoneNonspecific Hormone CaptureSPRyarn platformEE 2fiber yarnsDEScyclodextrin-modified celluloseeutectic solutionwood fiberCyclodextrin-Functionalized Fiber Yarns Spunbioactive yarnsCellulose fiber yarnsDeep Eutectic Cellulose SolutionsSurface Plasmon Resonancecholine chloride-ureaconjugation reactions